A neutron diffraction study of deformation in a cast uranium has been conducted for the first time. Lattice-scale plasticity in this coarse-grained material initiates at a lower stress than in a previous study of fine-grained material in the literature. This is attributed to a combination of larger thermal residual stresses in the coarse-grained material and the Hall-Petch effect making twinning easier in large grains. Asymmetry between the tensile and compressive response shows that twinning is the dominant plastic deformation mechanism at low strains. Axial texture changes for the cast uranium were calculated by post processing of the full diffraction spectra, which shows that lattice rotations associated with twinning occurred at yield. This lattice rotation was observed to disappear after unloading, which indicates that de-twinning can occur in uranium.