Bridging structure and performance at the nanoscale for advanced mRNA vaccine delivery
Prof M Stevens (Engineering) and Prof P D Nellist (Materials)
Nanocarriers have revolutionized medicine, notably expediting anti-COVID-19 vaccine development. Yet the major obstacle in their clinical application is the challenging control of nanoscale particle synthesis, leading to heterogeneity and impeding manufacturing and regulatory processes. This project aims to enhance organic and inorganic nanoformulations for mRNA vaccine delivery by leveraging the unparalleled insights into the structure-function-performance relationship, enabled by the combination of SPARTA® analysis (Molly Stevens’ group) and high-resolution electron imaging (Peter Nellist’s group).
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