Nanozyme-enhanced diagnostics: leveraging structural insights for performance optimisation

Dr Paul Bagot

Prof. Dame Molly Stevens

The COVID-19 pandemic has familiarised us all with the significance of point-of-care diagnostic tools for rapid, reliable and accessible testing. Nanozymes (nanomaterials having similar properties to biological enzymes), with their exception catalytic properties and stability, hold the promise of unmatches sensitivity for point-of-care diagnostic biosensors. Atom probe tomograpy will be used to characterise selected nanozymes produced by Prof. Dame Molly Stevens' group (https://eng.ox.ac.uk/people/molly-stevens/), with gained new insights into structure-function relationships leveraged to optimise the new generations of nanozymes for enhanced CRISPR-based diagnostics.

This project is within the Inorganic Materials for Advanced Manufacturing Centre for Doctoral Training (IMAT CDT), an EPSRC-funded centre focused on training the next generation of scientists. Our focus is on inorganic materials – spanning design, synthesis and characterisation and focusing on the raw materials, process and products – and our goal is to equip and enable a new generation of scientists capable of addressing critical societal challenges.

https://imatcdt.chem.ox.ac.uk/

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